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ASN: Particulate Matter at Ground Zero, Albuminuria Linked
For first responders, significant linear trend between exposure level, albumin-to-creatinine ratio

MONDAY, Nov. 11 (HealthDay News) -- For first responders exposed to particulate matter at Ground Zero, high exposure is associated with albuminuria, according to a study presented at the annual meeting of the American Society of Nephrology (Kidney Week), held from Nov. 5 to 10 in Atlanta.

Mary Ann McLaughlin, M.D., from the Mount Sinai School of Medicine in New York City, and colleagues assessed 183 first responders who were exposed to particulate matter at Ground Zero at the Word Trade Center to investigate the association with renal endothelial damage. An exposure score was calculated according to proximity to Ground Zero, time of arrival, and duration of exposure.

The researchers observed a significant linear trend between the level of particulate matter exposure and the albumin-to-creatinine ratio (P = 0.009). After adjustment for age, gender, race, smoking status, body mass index, glycated hemoglobin, and hypertension, compared with the low-exposure group, participants with the highest exposure had a 207 µg/mg greater albumin-to-creatinine ratio.

"We observed a statistically significant independent relationship of high exposure to particulate matter with albuminuria in this cohort after controlling for pertinent risk factors," the authors write. "This novel finding paves the way for future studies of environmental exposures and inflammation in the pathogenesis of albuminuria."

Several authors disclosed financial ties to the pharmaceutical industry.

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