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Plastics Chemical BPA Tied to Asthma in Inner-City Youth
Increased risk for wheeze at ages 5 and 6 seen even with low doses of exposure in 3-year-olds

WEDNESDAY, March 6 (HealthDay News) -- Urinary concentrations of bisphenol A (BPA) are significantly associated with asthma in inner-city children, according to a study published in the March issue of the Journal of Allergy and Clinical Immunology.

Kathleen M. Donohue, M.D., from Columbia University in New York City, and colleagues recruited 568 pregnant women for a prospective birth cohort study. Urine samples were collected from mothers during the third trimester and from children at ages 3, 5, and 7 years. Online solid-phase extraction, high-performance liquid chromatography, isotope-dilution tandem mass spectrometry was used to measure urinary BPA concentrations. Questionnaires at ages 5, 6, and 7 years were used to measure wheezing, and physicians determined asthma status between ages 5 and 12 years. Fraction of exhaled nitric oxide (FENO) values were measured at ages 7 to 11 years.

The researchers found that prenatal urinary BPA concentrations were significantly inversely associated with wheeze at age 5 years. Wheeze at ages 5 and 6 years was significantly positively associated with urinary BPA concentrations at age 3 years. At 7 years, BPA concentrations and wheeze were significantly associated. BPA concentrations at 7 years were also significantly associated with FENO values. Asthma and BPA concentrations at ages 3, 5, and 7 years were significantly associated.

"This is the first report of an association between postnatal urinary BPA concentrations and asthma in children," write the authors.

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